Pediatric-onset aspirin-exacerbated respiratory disease: Clinical characteristics, prevalence, and response to dupilumab

We describe a series of six cases of pediatric AERD seen and evaluated at our AERD Center. All six of them had such severe asthma or had failed so many prior therapies that they who ultimately initiated treatment with dupilumab, and subsequently all six of them reported good therapeutic response. We found that the clinical characteristics of pediatric-onset AERD are indistinguishable from those observed in adult patients. Further, we report that female patients with AERD are more likely to have developed their AERD in childhood, and that overall pediatric-onset AERD is more common than previously thought, with >6% of all patients with AERD reporting disease onset in childhood.