What is AERD/Samter’s Triad?

Aspirin tablet, 94084869Aspirin Exacerbated Respiratory Disease (AERD), also known as Samter’s Triad or Aspirin Sensitive Asthma, is a chronic medical condition that consists of asthma, recurrent sinus disease with nasal polyps, and a sensitivity to aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs). Approximately 10% of all adults with asthma and 40% of patients with asthma and nasal polyps are sensitive to aspirin and NSAIDs.

What are the symptoms?

Patients with AERD/Samter’s Triad usually have asthma, nasal congestion, and nasal polyps, and often do not respond to conventional treatments. Many have experienced chronic sinus infections and can lose their sense of smell. The characteristic feature of AERD/Samter’s Triad is that patients develop reactions triggered by aspirin or other NSAIDs.

These reactions can include:

  • Increased nasal congestion or stuffiness
  • Eye watering or redness
  • Cough, wheezing, or chest tightness
  • Frontal headache or sensation of sinus pain
  • Flushing and/or a rash
  • Nausea and/or abdominal cramping
  • General feeling of malaise, sometimes accompanied by dizziness

Latest News & Information
03May 19

Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-Exacerbated Respiratory Disease: A Prospective Trial

In a study conducted here at Brigham and Women’s, researcher Cahill et al. sought to explore the longitudinal changes in biomarkers of patient’s with AERD who take high-dose aspirin therapy. A total of 57 patients were enrolled, 42 with AERD and 15 with aspirin-tolerant asthma (ATAs). Participants with AERD were desensitized to aspirin and placed on high-dose aspirin treatment (1300 mg daily), and the control population of ATAs were given the same dose of aspirin. After 8 weeks, samples of blood and urine were collected and analyzed for known markers of Type 2 inflammation. Surprisingly, the patients with AERD showed an increase in several markers of inflammation after 8 weeks on aspirin therapy, despite reporting a decrease in nasal symptoms. The increase was not seen in patients with aspirin-tolerant asthma, suggesting that the effects of high-dose aspirin on patients with AERD may be unique to the disease.

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07Mar 19

New Staff Member!

The AERD Center is proud to announce the addition of Dr. Lily Li to the clinical staff at Brigham Allergy! Dr. Li will be running an allergy clinic for patients with a history of aspirin & NSAID reactions. She attended the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and completed her residency in Internal Medicine at New York-Presbyterian Hospital Weill Cornell Medical Center. She is in her second year in fellowship in Allergy at Brigham and Women’s Hospital. Her research Interests include diagnosing and improving care for patients with listed NSAID allergies including screening those patients who may require alternative pain medications. She is currently in the process of developing a pathway for allergist to evaluate and provide safer pain management for NSAID-allergic patients.

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17Jan 19

Aspirin-Exacerbated Respiratory Disease (NEJM – September, 2018)

Aspirin-Exacerbated Respiratory Disease

This manuscript from the Scripps AERD Center in California gives an all-encompassing picture of Aspirin-Exacerbated Respiratory Disease. In this comprehensive review, Drs. White and Stevenson aim to educate readers on the history of AERD, classical reactions to NSAIDs, diagnosis, prevalence of the disease, and available medical & surgical treatment. It is heartening to see the New England Journal of Medicine highlight this important disease since awareness is one of the greatest barriers to care in AERD. The Scripps Clinic in La Jolla, CA has a very active AERD Center. To learn more about them and their research head over to https://goo.gl/vD51CB.

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