What is AERD/Samter’s Triad?

Aspirin tablet, 94084869Aspirin Exacerbated Respiratory Disease (AERD), also known as Samter’s Triad or Aspirin Sensitive Asthma, is a chronic medical condition that consists of asthma, recurrent sinus disease with nasal polyps, and a sensitivity to aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs). Approximately 10% of all adults with asthma and 40% of patients with asthma and nasal polyps are sensitive to aspirin and NSAIDs.

What are the symptoms?

Patients with AERD/Samter’s Triad usually have asthma, nasal congestion, and nasal polyps, and often do not respond to conventional treatments. Many have experienced chronic sinus infections and can lose their sense of smell. The characteristic feature of AERD/Samter’s Triad is that patients develop reactions triggered by aspirin or other NSAIDs.

These reactions can include:

  • Increased nasal congestion or stuffiness
  • Eye watering or redness
  • Cough, wheezing, or chest tightness
  • Frontal headache or sensation of sinus pain
  • Flushing and/or a rash
  • Nausea and/or abdominal cramping
  • General feeling of malaise, sometimes accompanied by dizziness

Latest News & Information
17Jul 18

Aspirin-exacerbated respiratory disease: not always “adult-onset”.

Aspirin-exacerbated respiratory disease: not always “adult-onset”.

The AERD Center at Brigham and Women’s Hospital in Boston, MA collected a detailed clinical history from 227 patient with AERD within their AERD Patient Registry. Although AERD is generally considered to be a disease that begins only in adults, 3.5% of the patients (8 of 227) reported that they developed nasal polyps and AERD before the age of 18. This publication presents three pediatric cases of AERD who each developed the full triad of AERD/Samter’s Triad symptoms at the ages of 11, 8, and 13 years old. These cases and review of the AERD Patient Registry illustrate that the diagnosis of AERD must also be carefully considered in children who present with these symptoms.

read more
16Dec 15

Zyflo CR (controlled-release zileuton)

Zyflo details

Zyflo CR is an asthma medication that inhibits the production of leukotrienes, inflammatory molecules that contribute to airway inflammation in patients with AERD. Zyflo CR is typically prescribed as two 600 mg pills that are taken twice a day; liver enzymes need to be checked periodically. If you are uninsured or your insurance does not cover the full cost of Zyflo CR, the new manufacturer will cover up to $2500 a month in out-of-pocket expenses. Recent backorder issues that patients may have experienced are now resolved. Please see the above link for more information.

read more