The cause of severe nasal polyposis in AERD is unknown. To understand the role of antibody-secreting cells in AERD, Buchheit et al. studied these cells in nasal polyps. They noted that polyp IgE and IgG4 levels were elevated in subjects…
Bronchiectasis is a chronic disease in which the lungs' bronchi (airway walls) are damaged and widened. In addition to scarred bronchi, symptoms include repeated sinus infections, coughing up mucus, and difficulty breathing. There are several risk factors for bronchiectasis including…
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complicated disease with no definitive cure. As with other complex diseases, experts largely agree that a multidisciplinary approach is the most beneficial for patients. We recommend that patients with CRSwNP seek care…
In November 2019, the NIH hosted the first-ever conference dedicated to chronic rhinosinusitis with nasal polyps (CRSwNP). Clinical experts from allergy and otolaryngology, along with scientific researchers met to discuss current treatments for the disease and directions for future research.…
In this paper, Drs. Cho, Hamilos, Han, and Laidlaw review the diagnoses and treatments for different types of chronic rhinosinusitis (CRS) . The two most commonly described phenotypes of CRS are CRS with nasal polyps (CRSwNP) and CRS without nasal…
This review by Drs. Tanya M. Laidlaw and Kathleen M. Buchheit provides an update on the existing studies of biologics as treatments for nasal polyposis and identifies potential future areas for further research. Chronic rhinosinusitis with nasal polyposis, which is…
In this study, researchers at Brigham and Women’s Hospital demonstrated the feasibility and safety of a 1-day aspirin desensitization procedure. Desensitization remains the standard of treatment for patients with AERD but it has historically been time consuming—sometimes taking 2 to…
The AERD Center at Brigham and Women's Hospital is happy to announce three new members to our team! Physician Assistant Jillian Bensko, research coordinator Deborah Gakpo, and lab technician Erin Lewis. After completing her undergraduate degree in Health and Exercise…
In a study conducted here at Brigham and Women’s, researcher Cahill et al. sought to explore the longitudinal changes in biomarkers of patient’s with AERD who take high-dose aspirin therapy. A total of 57 patients were enrolled, 42 with AERD…
The AERD Center is proud to announce the addition of Dr. Lily Li to the clinical staff at Brigham Allergy! Dr. Li will be running an allergy clinic for patients with a history of aspirin & NSAID reactions. She attended…