New Staff Member!
The AERD Center is proud to announce the addition of Dr. Lily Li to the clinical staff at Brigham Allergy! Dr. Li will be running an allergy clinic for patients with a history of aspirin & NSAID reactions. She attended…
Aspirin-Exacerbated Respiratory Disease (NEJM – September, 2018)
Aspirin-Exacerbated Respiratory Disease This manuscript from the Scripps AERD Center in California gives an all-encompassing picture of Aspirin-Exacerbated Respiratory Disease. In this comprehensive review, Drs. White and Stevenson aim to educate readers on the history of AERD, classical reactions to…
Depression symptoms and quality of life among individuals with Aspirin-Exacerbated Respiratory Disease
Depression symptoms and quality of life among individuals with Aspirin-Exacerbated Respiratory Disease This study, directed by Dr. Elina Jerschow’s group in New York, was the first to examine levels of depression and disease- and asthma-related quality of life among patients…
Eosinophilia-Associated Coronary Artery Vasospasm in Patients with AERD
Eosinophilia-Associated Coronary Artery Vasospasm in Patients with Aspirin-Exacerbated Respiratory Disease Some patients with AERD and increased eosinophil cells in their blood have reported angina-like chest pain that occurs at rest, responds to systemic corticosteroid/prednisone therapy, and is presumed to be…
Alcohol-induced respiratory symptoms improve after aspirin desensitization in patients with AERD
Alcohol-induced respiratory symptoms improve after aspirin desensitization in patients with aspirin-exacerbated respiratory disease This study, directed by Dr. John Bosso and the research team at the University of Pennsylvania, suggests that aspirin desensitization and treatment with high-dose daily aspirin may…
Aspirin-exacerbated respiratory disease: not always “adult-onset”.
Aspirin-exacerbated respiratory disease: not always “adult-onset”. The AERD Center at Brigham and Women’s Hospital in Boston, MA collected a detailed clinical history from 227 patient with AERD within their AERD Patient Registry. Although AERD is generally considered to be a…
Zyflo CR (controlled-release zileuton)
Zyflo details Zyflo CR is an asthma medication that inhibits the production of leukotrienes, inflammatory molecules that contribute to airway inflammation in patients with AERD. Zyflo CR is typically prescribed as two 600 mg pills that are taken twice a…
Patients with AERD who develop a skin rash and gastrointestinal symptoms with aspirin desensitization produce large amounts of prostaglandin D2.
Prostaglandin D2: A dominant mediator of aspirin-exacerbated respiratory disease. The AERD Center at Brigham and Women’s Hospital in Boston, MA collected clinical characteristics and biologic specimens from 29 patients with AERD undergoing an aspirin desensitization procedure. In addition to the…
Patients who tolerate daily low-dose aspirin may still have Aspirin-Exacerbated Respiratory Disease/Samter’s Triad.
Tolerance of daily low-dose aspirin does not preclude aspirin-exacerbated respiratory disease. The AERD Center at Brigham and Women’s Hospital in Boston, MA identified a group of 7 AERD/Samter’s Triad patients with recurrent nasal polyps who, at the time of AERD…
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