Eosinophilic asthma and nasal polyposis are hallmarks of aspirin-exacerbated respiratory disease (AERD), and IL-5 inhibition has been shown to provide therapeutic benefit. However, IL-5Rα is expressed on many cells in addition to eosinophils, and the mechanisms by which IL-5 inhibition…
A series of patients with AERD who developed COVID-19, including many who were treated with respiratory biologics for their baseline AERD, did not appear to experience increased morbidity compared to the general population with COVID19. This is reassuring to those…
As the director of one of the largest evaluation and treatment centers for patients with AERD in the world, Dr. Laidlaw is often asked how to approach the use of aspirin desensitization followed by high-dose aspirin therapy for patients with AERD in…
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common and heterogeneous inflammatory disease of the upper respiratory tract. Advances in our understanding of the immune mechanisms that drive the chronic respiratory inflammation that underlies CRSwNP have led to the generation…
We studied the patient-reported symptoms (SNOT-22 scores and ACT scores) and lung function (FEV1) of 1065 patients with AERD in our AERD Patient Registry. SNOT-22 scores significantly predict ACT scores and FEV1%, and ACT scores significantly predict FEV1%. Any ten-point increase…
This paper and the accompanying editorial discuss the potential importance of two relatively unexplored players in #AERD — macrophages and fatty acid and acyl carnitine metabolism. More research to come.
Even after aspirin desensitization, it’s important that patients with AERD continue to have aspirin listed as an allergy, because they are at risk for reactions if aspirin is stopped, or they are given higher doses. This paper describes patients who…
About 20% of patients with AERD develop a characteristic itchy rash during their aspirin/NSAID-induced reactions, in addition to their respiratory symptoms. We found that 14% of the 387 patients with AERD queried at the Brigham and Women’s Hospital since 2013…
The cause of severe nasal polyposis in AERD is unknown. To understand the role of antibody-secreting cells in AERD, Buchheit et al. studied these cells in nasal polyps. They noted that polyp IgE and IgG4 levels were elevated in subjects…