Zyflo CR (controlled-release zileuton)
Zyflo details Zyflo CR is an asthma medication that inhibits the production of leukotrienes, inflammatory molecules that contribute to airway inflammation in patients with AERD. Zyflo CR is typically prescribed as two 600 mg pills that are taken twice a…
Patients with AERD who develop a skin rash and gastrointestinal symptoms with aspirin desensitization produce large amounts of prostaglandin D2.
Prostaglandin D2: A dominant mediator of aspirin-exacerbated respiratory disease. The AERD Center at Brigham and Women’s Hospital in Boston, MA collected clinical characteristics and biologic specimens from 29 patients with AERD undergoing an aspirin desensitization procedure. In addition to the…
Patients who tolerate daily low-dose aspirin may still have Aspirin-Exacerbated Respiratory Disease/Samter’s Triad.
Tolerance of daily low-dose aspirin does not preclude aspirin-exacerbated respiratory disease. The AERD Center at Brigham and Women’s Hospital in Boston, MA identified a group of 7 AERD/Samter’s Triad patients with recurrent nasal polyps who, at the time of AERD…
Four subclasses (subphenotypes) of AERD: All AERD patients are not the same
Certain subphenotypes of aspirin-exacerbated respiratory disease distinguished by latent class analysis. AERD/Samter’s Triad is recognized as a distinct asthma phenotype, but the recent work of Dr. Ewa Nizankowska-Mogilnicka and the late Dr. Andrzej Szczeklik, now sheds new insights on the…
A mouse model of AERD: Prostaglandin E2 (PGE2) deficiency results in AERD-like phenotype
Prostaglandin E2 (PGE2) deficiency results in AERD-like phenotype. AERD/Samter’s Triad is characterized by mast cell activation with overproduction of cysteinyl leukotrienes following inhibition of COX-1 by medications like aspirin or NSAIDs. The cause of the mast cell activation that occurs…
Entire course at AAAAI 2013 dedicated to Samter’s Triad!
On February 22, 2013, at the annual meeting of the American Academy of Allergy, Asthma & Immunology in San Antonio TX, there was an entire day-long course dedicated to teaching and learning about AERD/Samter's Triad! This is the first…
Could eating chocolate reduce leukotrienes?
Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells. One study suggests that eating the right kind of chocolate can decrease leukotriene production. Leukotrienes are signaling molecules that are responsible for many allergic and inflammatory reactions.…
Tobacco smoke and AERD / Samter’s Triad
Smoking, environmental tobacco smoke, and aspirin-exacerbated respiratory disease. A study published in 2012 by a group of researchers at the Scripps Clinic in California found that childhood exposure to environmental tobacco smoke was associated with increased odds of developing AERD,…