Aspirin-exacerbated respiratory disease: not always “adult-onset”. The AERD Center at Brigham and Women’s Hospital in Boston, MA collected a detailed clinical history from 227 patient with AERD within their AERD Patient Registry. Although AERD is generally considered to be a…
Zyflo details Zyflo CR is an asthma medication that inhibits the production of leukotrienes, inflammatory molecules that contribute to airway inflammation in patients with AERD. Zyflo CR is typically prescribed as two 600 mg pills that are taken twice a…
Prostaglandin D2: A dominant mediator of aspirin-exacerbated respiratory disease. The AERD Center at Brigham and Women’s Hospital in Boston, MA collected clinical characteristics and biologic specimens from 29 patients with AERD undergoing an aspirin desensitization procedure. In addition to the…
Tolerance of daily low-dose aspirin does not preclude aspirin-exacerbated respiratory disease. The AERD Center at Brigham and Women’s Hospital in Boston, MA identified a group of 7 AERD/Samter’s Triad patients with recurrent nasal polyps who, at the time of AERD…
Certain subphenotypes of aspirin-exacerbated respiratory disease distinguished by latent class analysis. AERD/Samter’s Triad is recognized as a distinct asthma phenotype, but the recent work of Dr. Ewa Nizankowska-Mogilnicka and the late Dr. Andrzej Szczeklik, now sheds new insights on the…
Prostaglandin E2 (PGE2) deficiency results in AERD-like phenotype. AERD/Samter’s Triad is characterized by mast cell activation with overproduction of cysteinyl leukotrienes following inhibition of COX-1 by medications like aspirin or NSAIDs. The cause of the mast cell activation that occurs…
On February 22, 2013, at the annual meeting of the American Academy of Allergy, Asthma & Immunology in San Antonio TX, there was an entire day-long course dedicated to teaching and learning about AERD/Samter's Triad! This is the first…
Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells. One study suggests that eating the right kind of chocolate can decrease leukotriene production. Leukotrienes are signaling molecules that are responsible for many allergic and inflammatory reactions.…